Controlling the production of phytotoxin pyriculol in Pyricularia oryzae by aldehyde reductase

Abstract Pyricularia oryzae is one of the most devastating plant pathogens in world. This fungus produces several secondary metabolites including phytotoxin pyriculols, which are classified into 2 types: aldehyde form (pyriculol and pyriculariol) alcohol (dihydropyriculol dihydropyriculariol). Although interconversion between has been predicted, PYC10 gene for oxidation to known, responsible reduction unknown. Furthermore, previous studies have predicted that analogs biosynthesized via analogs. Herein, we demonstrated an aldo/keto reductase PYC7 congeners. The results indicate analogs, contradicting prediction. suggest P. controls amount pyriculol using two oxidoreductases, PYC10, thereby controlling bioactivity phytotoxin.